They have much to talk about together - not only are they both married to some of the world's most powerful men but they both consistently champion home designers and have developed confident, individual senses of style in their roles.
Michelle Obama today welcomed Samantha Cameron to Washington DC with a special mini-Olympics staged at the city's American University. The couple looked relaxed in each others' company as they joked with students and sports players.
As focused as they were on the job at hand - the event a nod to the fast-approaching London Olympic Games - the influential duo can't have failed to have noticed the riot of colour created by the meeting of their bright ensembles.
Proving that they are comfortable with bold wardrobe choices, the women could not be missed on the basketball court as their bright dayglo hues stood out from their royal blue surroundings.
Supporting the best of British designers, SamCam, 40, paired her black Joseph trousers and navy suede LK Bennett pumps with a fuschia top by Roksanda Illinic. Her black belt is by designer, Emilia Wickstead.
At her side was Mrs Obama, 48, striking as ever in an embellished bright yellow knitted cardigan paired with a ruffle-necked shirt and wide-legged white trousers.
The fashion-forward couple put different spins on the wardrobe faithful of smart, tailored trousers on the first of their official engagements on the short trip.
Earlier in the day, Ms Cameron flew the flag for British designers as she chose a Burberry coat, paired with the same Joseph trousers and LK Bennett shoes for her debut outfit on the first day of her husband's U.S. state visit.
The Prime Minister's wife looked thoroughly chic in the all-black ensemble - though she may have regretted buttoning it all the way to the top given the sweltering heat at the Baltimore, Maryland Airforce base the Camerons' British Airways flight landed at this afternoon, where temperatures reached towards the eighties.
The cropped trench, worn by Mrs Cameron and neatly belted in the middle, is from British fashion house Burberry's current Spring/Summer 2012 collection, and retails for around £1,200.