The Crown Prosecution Service confirmed that they, along with four others, will be taken to court over accusations of plotting to hide material from police.
But Mr and Mrs Brooks remained defiant, branding the decision 'weak and unjust' and blaming the 'unprecedented posturing' of the CPS before they appeared at separate police stations to answer their bail.
Today's charges are among the most dramatic developments of a controversy that has sent shockwaves through the British political establishment and rocked Rupert Murdoch's media empire to its core.
Wearing a black trouser suit, Mrs Brooks, 43, was filmed entering Lewisham police station, south London, while Mr Brooks was spotted leaving Hammersmith police station, in west London.
An hour later Mrs Brooks emerged from the station and was whisked off in a black BMW, refusing to answer questions.
Mrs Brooks faces three counts of conspiracy to pervert the course of justice, including that she removed boxes of material from the News International archive and tried to conceal documents, computers and other material from the multimillion-pound Scotland Yard inquiry.
The couple were first arrested in July after a bag containing a laptop, iPhone and paperwork was apparently found in a bin near their £1.5 million home in London's exclusive Chelsea Harbour.
They were charged today with Mrs Brooks' former PA Cheryl Carter, Head of Security at News International Mark Hanna, News International chauffeur Paul Edwards and security consultant Daryl Jorsling.
All six will appear at Westminster Magistrates' Court at a date yet to be decided.